Hoffmann R
Department of Dermatology, Philipps-Universität, Deutschhausstrasse 9, D-35033 Marburg, Germany.
Eur J Dermatol. 2001 Jul-Aug;11(4):296-300.
Androgenetic alopecia (AGA) is the most common type of hair loss in men and women. This continuous process results in a type of alopecia that follows a definite pattern in those individuals who are genetically predisposed. A genetic predisposition is a feature of AGA, but the predisposing genes are still unknown. Our understanding, however, of the hormonal effects on hair growth is far move advanced, and human hair follicles are not only targets for androgens, but also reveal an active androgen metabolism, with the ability to convert several androgens by different steroidogenic enzymes. Recent results suggest that the dermal papilla of the hair follicle expresses abundant type 2 5a-reductase, 3b-HSD and steroid sulfatase activity. Therefore, current information about the androgen metabolism in hair follicles is reviewed and the potential impact on future therapeutic approaches is discussed.
雄激素性脱发（AGA）是男性和女性中最常见的脱发类型。这种持续的过程导致一种脱发类型，在那些有遗传易感性的个体中遵循一定的模式。遗传易感性是AGA的一个特征，但易感基因仍不清楚。然而，我们对激素对毛发生长影响的理解要先进得多，人类毛囊不仅是雄激素的靶标，而且还显示出活跃的雄激素代谢，能够通过不同的类固醇生成酶转化多种雄激素。最近的结果表明，毛囊的真皮乳头表达丰富的2型5α-还原酶、3β-羟类固醇脱氢酶和类固醇硫酸酯酶活性。因此，本文综述了毛囊中雄激素代谢的当前信息，并讨论了其对未来治疗方法的潜在影响。
