Sawaya M E, Keane R W, Blume-Peytavi U, Mullins D L, Nusbaum B P, Whiting D, Nicholson D W
ARATEC Research PO Box 7, Ocala, FL 34478, USA.
Eur J Dermatol. 2001 Jul-Aug;11(4):304-8.
Finasteride has been shown to be an effective treatment for men with androgenetic alopecia (AGA) as it restores hair growth to miniaturized hair follicles on the top of the scalp [1]. Caspases are regulators of programmed cell death, and very likely some specific caspases may function as mediators of the hair growth cycle. It is unclear whether finasteride influences the regulation of apoptosis via caspases in the hair follicle. Very little information is available regarding the role of caspases present in human hair follicles in normal scalp and in androgenetic alopecia. In this study we have analyzed the family of caspases, 1-10 along with usurpin, and XIAP, in men with normal scalp and in men with androgenetic alopecia before and after 6 months treatment with 1 mg oral finasteride treatment. Caspases 1, 3, 8 and 9 were detected predominantly within the isthmic and infundibular hair follicle area for both normal and AGA patients, however the expression of all factors, especially caspase 3 was greater in the AGA group than in the normal scalp group. AGA men had the same caspase factors but with greater expression. In the same AGA men treated with finasteride for 6 months, the expression of these factors was similar to levels in the normal group. Results from our study indicate caspase 3 to be of primary importance in normal hair homeostasis and that DHT may be signaling greater expression of caspases, inducing apoptosis in androgenetic alopecia. In conclusion, DHT may selectively regulate the caspase genes which play an important role in signaling programmed cell death, affecting the hair growth cycle.
非那雄胺已被证明是治疗男性雄激素性脱发（AGA）的有效方法，因为它能使头皮顶部萎缩的毛囊恢复头发生长[1]。半胱天冬酶是程序性细胞死亡的调节因子，很可能某些特定的半胱天冬酶可能作为毛发生长周期的介质发挥作用。目前尚不清楚非那雄胺是否通过毛囊中的半胱天冬酶影响细胞凋亡的调节。关于正常头皮和雄激素性脱发患者毛囊中半胱天冬酶的作用，目前所知甚少。在本研究中，我们分析了正常头皮男性和雄激素性脱发男性在口服1毫克非那雄胺治疗6个月前后半胱天冬酶家族（1-10）以及 usurpin 和 XIAP 的情况。对于正常人和AGA患者，半胱天冬酶1、3、8和9主要在毛囊峡部和漏斗部区域检测到，然而，所有因子的表达，尤其是半胱天冬酶3在AGA组中的表达高于正常头皮组。AGA男性具有相同的半胱天冬酶因子，但表达更高。在接受非那雄胺治疗6个月的同一组AGA男性中，这些因子的表达与正常组水平相似。我们的研究结果表明，半胱天冬酶3在正常毛发稳态中起主要作用，而双氢睾酮（DHT）可能促使半胱天冬酶表达增加，从而在雄激素性脱发中诱导细胞凋亡。总之，DHT可能选择性地调节半胱天冬酶基因，这些基因在程序性细胞死亡信号传导中起重要作用，影响毛发生长周期。
