Guerciolini R, Radu-Radulescu L, Boldrin M, Dallas J, Moore R
F. Hoffmann-La Roche, Palo Alto, California, USA.
Obes Res. 2001 Jun;9(6):364-7. doi: 10.1038/oby.2001.47.
To compare the effects of chitosan and orlistat on fecal fat excretion.
A randomized, open-label, two-period sequential design study was used. A total of 12 healthy adult volunteers within 20% of their ideal body weight entered a 7-day run-in diet period before being randomized to orlistat (120 mg) or chitosan (890 mg) three times daily for 7 days. Subjects then crossed over treatment regimens for an additional 7-day period. Subjects followed a standardized diet (2500 kcal/d, 30% as fat) for the entire 21-day study. Feces were collected on days 4 to 7 of the run-in period (baseline) and during the two treatment periods. Mean daily fecal fat excretion was measured at baseline and during each treatment regimen.
Mean baseline fecal fat excretion for all subjects was 1.36 +/- 0.45 g/d. During orlistat treatment, mean fecal fat excretion significantly increased from baseline (+16.13 +/- 7.27 g/d; p < 0.001). No significant effect was observed with chitosan (+0.27 +/- 1.02 g/d; p = 0.379). Fecal fat excretion was significantly greater with orlistat than with chitosan (p < 0.001; 95% confidence intervals: 11.73; 20.00 g/d).
This study provides additional evidence of the inhibitory effect of orlistat on dietary fat absorption. Chitosan, however, has no effect on fecal fat excretion.
比较壳聚糖和奥利司他对粪便脂肪排泄的影响。
采用随机、开放标签、两阶段序贯设计研究。共有12名体重在理想体重20%以内的健康成年志愿者在进入为期7天的适应期饮食后，被随机分为每日三次服用奥利司他（120毫克）或壳聚糖（890毫克），持续7天。然后受试者交叉接受另一种治疗方案，为期7天。在整个21天的研究中，受试者遵循标准化饮食（2500千卡/天，30%为脂肪）。在适应期的第4至7天（基线）以及两个治疗期收集粪便。在基线和每个治疗方案期间测量每日平均粪便脂肪排泄量。
所有受试者的平均基线粪便脂肪排泄量为1.36±0.45克/天。在奥利司他治疗期间，平均粪便脂肪排泄量较基线显著增加（+16.13±7.27克/天；p<0.001）。壳聚糖治疗未观察到显著效果（+0.27±1.02克/天；p = 0.379）。奥利司他治疗后的粪便脂肪排泄量显著高于壳聚糖（p<0.001；95%置信区间：11.73；20.00克/天）。
本研究为奥利司他对膳食脂肪吸收的抑制作用提供了更多证据。然而，壳聚糖对粪便脂肪排泄没有影响。
