Nayar R, Frost A R
Department of Pathology, Northwestern University and The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL 60611, USA.
Semin Diagn Pathol. 2001 May;18(2):81-98.
The key to the interpretation of thyroid fine needle aspiration is largely dependent on the recognition of various morphologic patterns of epithelial cells, usually follicular cells, and background elements, such as colloid. These morphologic patterns consist of 3 parts: 1) The arrangement of cells with respect to one another, 2) The cytologic features of individual cells, and 3) The presence of background elements. The cellular arrangements generally encountered in fine needle aspiration of the thyroid include the follicular patterns (macro-/normo-follicular and micro-follicular), the papillary pattern, the syncytial pattern, the dispersed cell pattern, and the cystic pattern. This article approaches some of the differential diagnostic challenges encountered while interpreting thyroid aspiration cytology by focusing first on the overall cellular arrangement to generate a differential diagnosis and then narrowing that differential by assessing cellular features of individual cells and the presence of background elements.
甲状腺细针穿刺活检结果的解读关键很大程度上取决于对各种上皮细胞形态模式的识别，这些上皮细胞通常为滤泡细胞，同时还取决于对背景成分（如胶质）的识别。这些形态模式由三部分组成：1）细胞彼此之间的排列方式；2）单个细胞的细胞学特征；3）背景成分的存在情况。甲状腺细针穿刺活检中通常遇到的细胞排列方式包括滤泡模式（大/正常滤泡和微滤泡）、乳头模式、合体细胞模式、散在细胞模式和囊性模式。本文通过首先关注整体细胞排列以进行鉴别诊断，然后通过评估单个细胞的细胞学特征和背景成分的存在情况来缩小鉴别范围，探讨了在解读甲状腺穿刺细胞学检查时遇到的一些鉴别诊断挑战。
