Dubrovina N I, Gilinskiĭ M A, Il'iuchenok R Iu
Fiziol Zh SSSR Im I M Sechenova. 1975 Feb;61(2):193-8.
The effects of sodium glutamate, GABA, atropine, and acetylcholine microiontophoresis on the focal responses evoked by the stimulation of the forepaw and the contralateral hippocampus, were studied in unanesthetized immobilized rats. No significant changes were observed in sensory potentials following the application of these drugs. The microiontophoresis of glutamate to the recording site produced changes of the commissural responses. The positive wave was markedly depresses on 200-450 microns depth. At the same time the negative wave increased gradually in amplitude. In records from the layer of the apical dendritic shafts the negative commissural response component increased following local injection of glutamate. GABA failed to evoke changes in the commissural response though prevented the effect of glutamate. The possible differences in the mechanisms of commissural and sensory evoked potentials responsible for the effects observed are discussed.
在未麻醉的固定大鼠中，研究了谷氨酸钠、γ-氨基丁酸、阿托品和乙酰胆碱微离子透入对刺激前爪和对侧海马诱发的局灶性反应的影响。应用这些药物后，未观察到感觉电位有明显变化。将谷氨酸微离子透入记录部位会引起连合反应的变化。在200 - 450微米深度处，正波明显降低。同时，负波幅度逐渐增加。在顶树突轴突层的记录中，局部注射谷氨酸后，连合反应的负性成分增加。γ-氨基丁酸虽然能阻止谷氨酸的作用，但未能引起连合反应的变化。文中讨论了观察到的这些效应所涉及的连合诱发电位和感觉诱发电位机制的可能差异。
