Goodwin T J, Ormandy J E, Poulter R T
Department of Biochemistry, University of Otago, Cumberland Street, P.O. Box 56, Dunedin, New Zealand.
Curr Genet. 2001 Apr;39(2):83-91. doi: 10.1007/s002940000181.
Non-LTR retrotransposons (also known as LINEs) have had a major influence on the structure of many eukaryote genomes. They are abundant in many multicellular eukaryotes, including mammals, but appear to be absent from the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. This absence has, to date, precluded the development of a yeast model system for the study of non-LTR retrotransposons. In this report we describe several families of non-LTR retrotransposons from the yeast Candida albicans. These elements, which we call Zorro elements, are all members of the L1 clade of non-LTR retrotransposons. Some are intact, transcriptionally active and have transposed recently. This finding should allow the development of a yeast model system.
非长末端重复逆转录转座子（也称为长散在核元件）对许多真核生物基因组的结构产生了重大影响。它们在包括哺乳动物在内的许多多细胞真核生物中大量存在，但酿酒酵母和粟酒裂殖酵母中似乎没有。迄今为止，这种缺失阻碍了用于研究非长末端重复逆转录转座子的酵母模型系统的开发。在本报告中，我们描述了来自白色念珠菌的几个非长末端重复逆转录转座子家族。这些元件，我们称之为佐罗元件，都是非长末端重复逆转录转座子L1进化枝的成员。有些是完整的，具有转录活性，并且最近发生了转座。这一发现应该有助于开发酵母模型系统。
