一种用于两亲性双环肽库的硫酯连接方法。
A thioester ligation approach to amphipathic bicyclic peptide library.
作者信息
Sun Y, Lu G, Tam J P
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
出版信息
Org Lett. 2001 May 31;3(11):1681-4. doi: 10.1021/ol015889i.
PMID:11405685
Abstract
An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.
摘要
通过树脂上分子内硫酯连接和树脂外二甲基亚砜介导的二硫键形成，展示了一种从未保护肽合成两亲性双环肽库的有效方法。
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