First total synthesis of (+/-)-taxifolial a and (+/-)-iso-caulerpenyne.

作者信息

Commeiras L, Santelli M, Parrain J L

机构信息

Laboratoire de Synthèse Organique associé au CNRS (UMR 6009), Faculté des Sciences de Saint Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.

出版信息

Org Lett. 2001 May 31;3(11):1713-5. doi: 10.1021/ol015903r.

The first synthesis of (+/-)-taxifolial A and iso-caulerpenyne was accomplished. The key steps in the sequence are (1) the stereoselective assembly of a vinyltin derived from butynediol and a functionalized aldehyde and (2) the construction of the dienyne moiety via a Stille cross-coupling.