Zhou X, Kovalev E G, Klug J T, Khodorkovsky V
The Institutes for Applied Research and the Department of Chemistry, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 84105, Israel.
Org Lett. 2001 May 31;3(11):1725-7. doi: 10.1021/ol015918p.
Quantum mechanical calculations show that N,N cycloaddition of alkenes and alkynes to s-tetrazines is possible as an alternative to the well-known C,C cycloaddition (Carboni-Lindsey reaction). Formation of 1,2,4-triazole derivatives (formal product of N,N cycloaddition) along with the pyrazole (formal product of C,C cycloaddition) corroborates this theoretical prediction.
量子力学计算表明，烯烃和炔烃与s-四嗪的N,N环加成作为一种替代众所周知的C,C环加成（卡尔博尼-林赛反应）的方式是可能的。1,2,4-三唑衍生物（N,N环加成的形式产物）与吡唑（C,C环加成的形式产物）的形成证实了这一理论预测。
