环境温度氮导向二氟炔基硼烷 Carboni-Lindsey 环加成反应。
Ambient temperature nitrogen-directed difluoroalkynylborane Carboni-Lindsey cycloaddition reactions.
机构信息
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK.
出版信息
Org Lett. 2010 Jan 1;12(1):160-3. doi: 10.1021/ol902573x.
PMID:19954201
Abstract
The in situ generation of alkynyldifluoroboranes in the presence of N-heterocycle substituted tetrazines provides a convenient and direct method for the synthesis of pyridazine difluoroboranes. The reactions proceed in 10 min under ambient conditions and provide the opportunity to assemble unsymmetrical products with complete regiocontrol.
摘要
在 N-杂环取代的四嗪存在下原位生成炔基二氟硼烷，为合成哒嗪二氟硼烷提供了一种方便、直接的方法。反应在环境条件下 10 分钟内进行，并提供了完全区域控制的组装不对称产物的机会。
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