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Total synthesis of (-)- and (+)-dysibetaine.

作者信息

Snider B B, Gu Y

机构信息

Department of Chemistry, MS015, Brandeis University, Waltham, Massachusetts 02454-9110, USA.

出版信息

Org Lett. 2001 May 31;3(11):1761-3. doi: 10.1021/ol015954o.

DOI:10.1021/ol015954o
PMID:11405705
Abstract

Glycidamides 6R and 6S were elaborated to (R,R)- and (S,S)-dysibetaines (1R and 1S) by intramolecular alkylation and functional group modification in 23% overall yield. The absolute stereochemistry of natural dysibetaine was established as S,S by comparison of the optical rotation of the natural product with that of the synthetic materials.

摘要

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