小型核酶的结构与功能。

Structure and function of the small ribozymes.

作者信息

Butcher S E

机构信息

Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Drive, Madison, WI 53706, USA.

出版信息

Curr Opin Struct Biol. 2001 Jun;11(3):315-20. doi: 10.1016/s0959-440x(00)00207-4.

DOI:10.1016/s0959-440x(00)00207-4

PMID:11406380

Abstract

Recently, major advances have been made toward increasing our understanding of small ribozyme structure and function. The first general acid-base catalytic mechanism for a ribozyme has been defined. Shifted nucleotide pK(a) values have been found to be surprisingly frequent structural elements. Finally, the dynamic nature of RNA catalysis has been highlighted through new structural and biochemical information.

摘要

最近，在增进我们对小核酶结构和功能的理解方面取得了重大进展。已经确定了核酶的首个一般酸碱催化机制。已发现核苷酸pK(a)值的变化是极为常见的结构元件。最后，通过新的结构和生化信息突出了RNA催化的动态性质。