Drugeon H B, Courtieu A L
Ann Microbiol (Paris). 1979 Apr;130A(3):331-43.
The authors have studied on 20 bacterial strains (5 Pseudomonas aeruginosa, 5 Escherichia coli, 5 Klebsiella and 5 Serratia) the bactericidal kinetics of 4 aminoglycoside antibiotics: amikacin, gentamicin, kanamycin and tobramycin. The antibiotic concentrations used for this work were 1.5 times the MIC for each strain previously measured in a liquid medium. The action of the aminoglycoside antibiotics shows three phases. The third phase describes a part of less susceptible bacterial population. It permits the comparison of the 4 antibiotics. Amikacin shows the best activity, followed by gentamicin, kanamycin and tobramycin.
作者研究了20株细菌（5株铜绿假单胞菌、5株大肠杆菌、5株克雷伯菌和5株沙雷菌）对4种氨基糖苷类抗生素（阿米卡星、庆大霉素、卡那霉素和妥布霉素）的杀菌动力学。本研究中使用的抗生素浓度为先前在液体培养基中测得的每种菌株最低抑菌浓度（MIC）的1.5倍。氨基糖苷类抗生素的作用呈现三个阶段。第三阶段描述了一部分较不易感的细菌群体。这使得能够对这4种抗生素进行比较。阿米卡星表现出最佳活性，其次是庆大霉素、卡那霉素和妥布霉素。
