抗生素对单核细胞增生李斯特菌细胞内生长的抑制作用。
Inhibition of intracellular growth of Listeria monocytogenes by antibiotics.
作者信息
Michelet C, Avril J L, Cartier F, Berche P
机构信息
Clinique des Maladies Infectieuses, Centre Hospitalier Regional, Paris, France.
出版信息
Antimicrob Agents Chemother. 1994 Mar;38(3):438-46. doi: 10.1128/AAC.38.3.438.
Abstract
We studied the activities of 15 antibiotics on the intracellular growth of Listeria monocytogenes in a HeLa cell line. After 24 h of contact with the infected cells, the antibiotics most effective against the intracellular growth of the 10 strains tested were amoxicillin, temafloxacin, and sparfloxacin, which nevertheless failed to totally eliminate the intracellular bacteria. Rifampin and co-trimoxazole had variable effects, depending on the isolates studied. The most active combinations were amoxicillin-sparfloxacin, co-trimoxazole-gentamicin, and sparfloxacin-co-trimoxazole. The results suggest the value of using a cell culture technique to study the activities of antibiotics against certain bacteria with intracellular sites of multiplication.
摘要
我们研究了15种抗生素对单核细胞增生李斯特菌在HeLa细胞系内生长的活性。在与感染细胞接触24小时后，对所测试的10株菌株的细胞内生长最有效的抗生素是阿莫西林、替马沙星和司帕沙星，然而它们未能完全清除细胞内的细菌。利福平与复方新诺明的效果因所研究的菌株而异。最有效的组合是阿莫西林-司帕沙星、复方新诺明-庆大霉素和司帕沙星-复方新诺明。结果表明，使用细胞培养技术研究抗生素对某些在细胞内繁殖部位的细菌的活性具有重要价值。
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