Noto R, Rapisarda A, Mirabella C, Landolina C, Meli S, Leanza A, Quartarone D, Rizzo S, Sciacchitano G
Istituto di Medicina Interna e Medicina d'Urgenza, Università degli Studi di Catania, Italy.
Eur Rev Med Pharmacol Sci. 2000 Jan-Apr;4(1-2):25-30.
Changes in the metabolic hormonal balance during the climacteric and menopause, especially surgically induced menopause, increase the risk of acute cerebrocardiovascular complications. This major risk may be linked to changes in blood pressure. In this study we performed twenty-four ambulatory blood pressure monitoring in climacteric (C), menopausal (PM), and surgically induced menopausal women (SM) to determine mean diurnal and nocturnal systodiastolic levels and percentage peaks, as variations in the pressure profile may be linked to organ damage. Our results showed that the entire series presented mainly diastolic increments (mDBP: HPM = 104.4 +/- 5.1; HSM = 106.3 +/- 2.9; HC = 100.2 +/- 3.1), and that this rise was greater in surgically induced menopausal women. In addition, these subjects presented the highest diastolic and systolic pressure peaks (HSM 37/42 versus HPM 35/36 and HC 29/31) also during the night (nocturnal peak: HSM 15/19 versus HPM 10/12 and HC 5/15). Non dippers seem more exposed to cerebrocardiovascular disease. Our results revealed that climacteric patients affected by arterial hypertension (mSBP = 162.2 +/- 4.1; mDBP = 100.2 +/- 3.1; 24 h systolic peak % = 24, diastolic peak % = 24) during the climacteric presented the same levels as observed in conclaimed menopause (mSBP 165.2 +/- 5.5; mDBP = 104.2 +/- 5.1; 24 h systolic peak % = 28, diastolic peak % = 29). Therefore, 24 h blood pressure monitoring is able to show that the pressure changes in hypertensive climacteric and menopausal women and could detect women who are at a greater risk of organ damage.
更年期和绝经期间，尤其是手术引起的绝经，代谢激素平衡的变化会增加急性心脑血管并发症的风险。这一主要风险可能与血压变化有关。在本研究中，我们对更年期（C）、绝经后（PM）和手术引起绝经的女性（SM）进行了24小时动态血压监测，以确定平均昼夜和夜间收缩压和舒张压水平以及峰值百分比，因为血压曲线的变化可能与器官损伤有关。我们的结果表明，整个系列主要表现为舒张压升高（平均舒张压：HPM = 104.4 +/- 5.1；HSM = 106.3 +/- 2.9；HC = 100.2 +/- 3.1），并且这种升高在手术引起绝经的女性中更大。此外，这些受试者在夜间也出现了最高的舒张压和收缩压峰值（HSM为37/42，而HPM为35/36，HC为29/31）（夜间峰值：HSM为15/19，而HPM为10/12，HC为5/15）。非勺型血压者似乎更容易患心脑血管疾病。我们的结果显示，更年期患有动脉高血压的患者（平均收缩压 = 162.2 +/- 4.1；平均舒张压 = 100.2 +/- 3.1；24小时收缩压峰值百分比 = 24，舒张压峰值百分比 = 24）在更年期的血压水平与确诊绝经患者（平均收缩压165.2 +/- 5.5；平均舒张压 = 104.2 +/- 5.1；24小时收缩压峰值百分比 = 28，舒张压峰值百分比 = 29）中观察到的水平相同。因此，24小时血压监测能够显示高血压更年期和绝经后女性的血压变化，并能检测出器官损伤风险更高的女性。
