Arena R, Humphrey R
Department of Physical Therapy, Box 980224, Virginia Commonwealth University, Medical College of Virginia, Health Sciences Campus, Richmond, VA 23298-0224, USA.
J Cardiopulm Rehabil. 2001 May-Jun;21(3):130-4. doi: 10.1097/00008483-200105000-00002.
This study investigates the relationship between ventilatory expired gas and cardiac parameters measured during exercise testing in patients with heart failure.
Twenty-five subjects (12 male, 13 female) diagnosed with compensated heart failure underwent symptom-limited exercise testing with ventilatory expired gas analysis. Metabolic and cardiac measures of interest were collected during testing.
Mean peak oxygen consumption (VO2), minute ventilation/carbon dioxide production (VE/VCO2) slope, percentage of age predicted maximal heart rate achieved during exercise testing (%APMHR), and peak respiratory exchange ratio were 14.7 +/- 4.7 mL O2/kg/min-1, 33.8 +/- 9.8, 76% +/- 15%, and 1.1 +/- 0.11, respectively. The VE/VCO2 slope was significantly correlated with the following: %APMHR (r = -0.81, P < 0.001), peak VO2 (r = -0.83, P < 0.001), VO2 at ventilatory threshold (r = -0.70, P < 0.001), and the dead space to tidal volume ratio (VD/Vt) (r = 0.65, P < 0.001). The ability of peak VO2 and %APMHR to predict the VE/VCO2 slope was significant (r = 0.86, r2 = 0.72, P < 0.0001).
This study demonstrates the importance of analyzing multiple exercise test parameters, including metabolic measures, in patients with heart failure.
本研究调查心力衰竭患者运动试验期间测量的通气呼出气体与心脏参数之间的关系。
25名被诊断为代偿性心力衰竭的受试者（12名男性，13名女性）接受了症状限制运动试验及通气呼出气体分析。在试验期间收集了感兴趣的代谢和心脏指标。
平均峰值耗氧量（VO₂）、分钟通气量/二氧化碳产生量（VE/VCO₂）斜率、运动试验期间达到的年龄预测最大心率百分比（%APMHR）以及峰值呼吸交换率分别为14.7±4.7 mL O₂/kg/min⁻¹、33.8±9.8、76%±15%和1.1±0.11。VE/VCO₂斜率与以下指标显著相关：%APMHR（r = -0.81，P < 0.001）、峰值VO₂（r = -0.83，P < 0.001）、通气阈值时的VO₂（r = -0.70，P < 0.001）以及死腔与潮气量之比（VD/Vt）（r = 0.65，P < 0.001）。峰值VO₂和%APMHR预测VE/VCO₂斜率的能力显著（r = 0.86，r² = 0.72，P < 0.0001）。
本研究证明了分析心力衰竭患者多个运动试验参数（包括代谢指标）的重要性。
