Bo S, Cavallo-Perin P, Ciccone G, Scaglione L, Pagano G
Department of International Medicine, University of Torino, Torino, Italy.
Exp Clin Endocrinol Diabetes. 2001;109(3):135-40. doi: 10.1055/s-2001-14835.
To evaluate if being a twin is a condition at risk of developing metabolic abnormalities in the adult life 'per se' or as a consequence of the lower birth weight.
48 monozygotic twins and 50 non-twin controls, both with parental diabetes, were compared; the two groups were comparable for age, sex and body mass index.
Twins showed higher values of blood pressure, triglycerides, insulin resistance, fasting insulin, insulin AUCs and higher prevalence of the metabolic syndrome, and, inversely, lower birth weight. After adjustment for birth weight, no significant association was evident with the twin status. Birth weight was inversely associated with the presence of the metabolic syndrome or of at least one or more of its components, while the positive association with the twin status was not significant.
Our data suggest that low birth weight is more relevant than the twin status as a risk factor for the metabolic syndrome and its components.
评估双胞胎本身是否是成年后发生代谢异常的风险因素，还是因出生体重较低所致。
比较了48对单卵双胞胎和50名非双胞胎对照者，两组在年龄、性别和体重指数方面具有可比性，且父母均患有糖尿病。
双胞胎的血压、甘油三酯、胰岛素抵抗、空腹胰岛素、胰岛素曲线下面积值更高，代谢综合征患病率更高，而出生体重更低。在对出生体重进行校正后，双胞胎状态与这些指标无明显关联。出生体重与代谢综合征或其至少一种或多种组分呈负相关，而与双胞胎状态的正相关不显著。
我们的数据表明，作为代谢综合征及其组分的风险因素，低出生体重比双胞胎状态更具相关性。
