Valenzuela O F, Reiser I W, Porush J G
Division of Nephrology and Hypertension, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA.
J Nephrol. 2001 Mar-Apr;14(2):120-4.
We report a 28-year-old male who presented with a clinical picture compatible with idiopathic polymyositis and nephrotic-range proteinuria. Muscle biopsy confirmed the diagnosis of polymyositis and a diagnostic renal biopsy demonstrated IgM mesangial glomerulonephritis. Following a short-course of prednisone, both the myositis and proteinuria resolved. Glomerulonephritis associated with idiopathic polymyositis is rare; however, since it appeared to respond to corticosteroid therapy concomitant with the improvement in the myositis, it was likely an associated immunological complication.
我们报告了一名28岁男性,其临床表现符合特发性多肌炎及肾病范围蛋白尿。肌肉活检确诊为多肌炎,诊断性肾活检显示为IgM系膜增生性肾小球肾炎。经过短期泼尼松治疗后,肌炎和蛋白尿均消失。与特发性多肌炎相关的肾小球肾炎较为罕见;然而,由于其似乎对皮质类固醇治疗有反应,同时肌炎也有所改善,所以这可能是一种相关的免疫并发症。