Ohara K, Furuyama F, Isobe Y
J Appl Physiol. 1975 Apr;38(4):724-9. doi: 10.1152/jappl.1975.38.4.724.
The response pattern of the rectal temperature of unanesthetized rats exposed to an acute heat in a room of 42.5 degrees C, rh 40% was analyzed in relation to survival time (S), equilibrium rectal temperature (Te), rise in Te from the initial temperature (Delta Te), and the slope of the changes in rectal temperature during the equilibrium period (Gt). A very wide fluctuation of the survival time (from 46.8 to 250.0 min) was observed between individual rats. For prediction of the survival time, following formula was obtained: log(S) = K1 - K2 times log (Te) - K3 times log (Delta Te) + k4 times 10- minus Gt. K1-4 are constants which differ according to sex. The predicted survival time showed highly constant results in individual rats when measured by repeated exposures. The predicted time coincided well with the survival time actually measured, the difference between the two (measured minus predicted) being 2.2 plus or minus 21.7 min (mean plus or minus SD) IN 77 RATS. There was also a significant correlation between the survival time predicted for acute heat exposure and the actual survival time of individual rats when they were exposed to a chronic heat by daily elevation of the rearing room temperature by 1.0 degrees C.
分析了在42.5摄氏度、相对湿度40%的房间中急性受热的未麻醉大鼠的直肠温度响应模式，该模式与存活时间（S）、平衡直肠温度（Te）、Te相对于初始温度的升高幅度（ΔTe）以及平衡期直肠温度变化的斜率（Gt）相关。观察到个体大鼠之间的存活时间波动非常大（从46.8分钟到250.0分钟）。为了预测存活时间，得到了以下公式：log(S)=K1 - K2×log(Te) - K3×log(ΔTe)+k4×10^(-Gt)。K1 - 4是根据性别而不同的常数。通过重复暴露测量时，预测的存活时间在个体大鼠中显示出高度一致的结果。预测时间与实际测量的存活时间吻合良好，在77只大鼠中，两者之差（测量值减去预测值）为2.2±21.7分钟（平均值±标准差）。当通过每天将饲养室温度升高1.0摄氏度使个体大鼠暴露于慢性热环境时，急性热暴露预测的存活时间与实际存活时间之间也存在显著相关性。
