海鞘胺A的合成与绝对构型：一种可诱导海鞘幼虫变态的海洋生物碱。

Synthesis and absolute configuration of Stellettadine A: a marine alkaloid that induces larval metamorphosis in ascidians.

作者信息

Nozawa D, Takikawa H, Mori K

机构信息

Department of Chemistry, Faculty of Science, Science University of Tokyo, Kagurazaka 1-3, Shinjuku-ku, Tokyo 162-8601, Japan.

出版信息

Bioorg Med Chem Lett. 2001 Jun 18;11(12):1481-3. doi: 10.1016/s0960-894x(01)00015-4.

DOI:10.1016/s0960-894x(01)00015-4

PMID:11412965

Abstract

Stellettadine A, a bisguanidinium alkaloid isolated from a marine sponge Stelletta sp. as an inducer of larval metamorphosis in ascidians, and its unnatural enantiomer were synthesized from the enantiomers of citronellal. The absolute configuration of stellettadine A was established as R.

摘要

从海绵动物Stelletta sp.中分离得到的双胍生物碱A（一种海鞘幼虫变态诱导剂）及其非天然对映体由香茅醛的对映体制备而成。确定了双胍生物碱A的绝对构型为R。