Wu Qihao, Nay Bastien, Yang Min, Ni Yeke, Wang Hong, Yao Ligong, Li Xuwen
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China.
Acta Pharm Sin B. 2019 Mar;9(2):237-257. doi: 10.1016/j.apsb.2018.10.003. Epub 2018 Oct 16.
Marine sponges of the genus are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
属的海洋海绵作为多种复杂且与生物相关的天然产物的丰富来源而广为人知，这些天然产物包括生物碱、萜类化合物、肽、脂质和类固醇。其中一些代谢产物具有新颖的结构和有前景的生物活性，吸引了众多化学家的关注，他们试图在对新药物先导物进行深入生物学研究的同时进行其全合成。在本综述中，我们总结了经化学研究的海绵的分布情况、其次级代谢产物的分离、合成及生物活性，涵盖了1982年至2018年初的文献。
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