Why there are two cyclooxygenase isozymes.
作者信息
Smith W L, Langenbach R
机构信息
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA.
出版信息
J Clin Invest. 2001 Jun;107(12):1491-5. doi: 10.1172/JCI13271.
Abstract
摘要
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本文引用的文献
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Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways.前列腺素生成的非传统途径：环氧合酶起始途径中的新变化
J Clin Invest. 2001 Jun;107(12):1481-9. doi: 10.1172/JCI13375.
2
Regulated formation of eicosanoids.类二十烷酸的调控生成。
J Clin Invest. 2001 Jun;107(11):1347-51. doi: 10.1172/JCI13241.
3
Arachidonic acid as a bioactive molecule.花生四烯酸作为一种生物活性分子。
J Clin Invest. 2001 Jun;107(11):1339-45. doi: 10.1172/JCI13210.
4
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2.环氧合酶-1和环氧合酶-2缺陷的新生小鼠动脉导管闭合和重塑失败。
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1059-64. doi: 10.1073/pnas.98.3.1059. Epub 2001 Jan 23.
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Disruption of cyclooxygenase-1 gene results in an impaired response to radiation injury.环氧化酶-1基因的破坏导致对辐射损伤的反应受损。
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Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.Ptgs-1以及Ptgs-2的基因破坏可减少Min小鼠的肠道肿瘤发生。
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NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.非甾体抗炎药诱导的大鼠胃损伤：同时抑制环氧化酶1和2的必要性。
Gastroenterology. 2000 Sep;119(3):706-14. doi: 10.1053/gast.2000.16510.
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Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.通过环氧化酶-2将内源性大麻素2-花生四烯酸甘油酯氧化为甘油基前列腺素。
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Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.在前列腺素E2快速生物合成过程中与环氧化酶-1功能偶联的胞质型前列腺素E2合成酶的分子鉴定。
J Biol Chem. 2000 Oct 20;275(42):32775-82. doi: 10.1074/jbc.M003504200.
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