奥美拉唑对健康男性志愿者中缓释卡马西平药代动力学的影响。
Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers.
作者信息
Dixit R K, Chawla A B, Kumar N, Garg S K
机构信息
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
出版信息
Methods Find Exp Clin Pharmacol. 2001 Jan-Feb;23(1):37-9. doi: 10.1358/mf.2001.23.1.619178.
The present study shows the effect of omeprazole administration on the pharmacokinetics of a sustained-release preparation of carbamazepine in healthy male volunteers. Multiple dose administration of omeprazole increased the Cmax, AUC0-infinity and elimination half life (t1/2e) of carbamazepine. The results suggest that drug monitoring should be carried out when carbamazepine is coadministered with omeprazole.
本研究显示了奥美拉唑给药对健康男性志愿者中卡马西平缓释制剂药代动力学的影响。多次给予奥美拉唑增加了卡马西平的Cmax、AUC0-无穷大及消除半衰期（t1/2e）。结果表明，当卡马西平与奥美拉唑合用时应进行药物监测。
Zotero 插件