Garg S K, Islam A S, Kumar N
Department of Pharmacology, Postgraduate Institute Of Medical Education and Research, Chandigarh.
Indian J Physiol Pharmacol. 1998 Oct;42(4):527-32.
The study was carried out in rabbits, to see the effects of Septilin, a herbal preparation on the single and multiple dose kinetics of carbamazepine. Single dose treatment of Septilin significantly decreased t 1/2a. t 1/2e. AUCo-alpha of carbamazepine. Steady state Cmax and AUC0-24 of carbamazepine were also reduced significantly in comparison to those of control rabbits after 7 days co-administration of Septilin. We conclude that Septilin decrease/hinder the absorption process of carbamazepine through an unknown mechanism.
该研究在兔子身上进行，以观察一种草药制剂Septilin对卡马西平单剂量和多剂量动力学的影响。Septilin单剂量治疗显著降低了卡马西平的t 1/2a、t 1/2e和AUCo-α。与对照兔相比，在联合使用Septilin 7天后，卡马西平的稳态Cmax和AUC0-24也显著降低。我们得出结论，Septilin通过未知机制降低/阻碍了卡马西平的吸收过程。
