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Chronic beryllium disease: T cell recognition of a metal presented by HLA-DP.

作者信息

Fontenot A P, Newman L S, Kotzin B L

机构信息

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

出版信息

Clin Immunol. 2001 Jul;100(1):4-14. doi: 10.1006/clim.2001.5053.

DOI:10.1006/clim.2001.5053
PMID:11414740
Abstract
摘要

相似文献

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Chronic beryllium disease: T cell recognition of a metal presented by HLA-DP.慢性铍病:HLA - DP呈递金属的T细胞识别
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2
Beryllium presentation to CD4+ T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease.铍呈递给CD4+ T细胞是慢性铍病中疾病易感性HLA-DP等位基因的基础。
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Beryllium presentation to CD4+ T cells is dependent on a single amino acid residue of the MHC class II beta-chain.铍向CD4+ T细胞的呈递取决于MHC II类β链的单个氨基酸残基。
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Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease.主要组织相容性复合体II类分子在铍致敏和慢性铍病易感性中的作用
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Recombinant HLA-DP2 binds beryllium and tolerizes beryllium-specific pathogenic CD4+ T cells.重组 HLA-DP2 结合铍并使铍特异性致病性 CD4+ T 细胞产生耐受。
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Major histocompatibility locus genetic markers of beryllium sensitization and disease.铍致敏和疾病的主要组织相容性位点遗传标记。
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Activation pathways implicate anti-HLA-DP and anti-LFA-1 antibodies as lead candidates for intervention in chronic berylliosis.激活途径表明,抗HLA-DP和抗LFA-1抗体是干预慢性铍病的主要候选药物。
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HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease.针对铍的HLA - DP等位基因特异性T细胞反应导致了与DP相关的慢性铍病易感性。
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HLA-DP-unrestricted TNF-alpha release in beryllium-stimulated peripheral blood mononuclear cells.铍刺激的外周血单个核细胞中不受HLA-DP限制的肿瘤坏死因子-α释放
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Beryllium-induced tumor necrosis factor-alpha production by CD4+ T cells is mediated by HLA-DP.铍诱导CD4 + T细胞产生肿瘤坏死因子-α是由HLA - DP介导的。
Am J Respir Cell Mol Biol. 2004 Jul;31(1):122-30. doi: 10.1165/rcmb.2003-0336OC. Epub 2004 Feb 19.

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Immunotoxicology of beryllium lung disease.铍肺疾病的免疫毒理学。
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Chronic beryllium disease: an updated model interaction between innate and acquired immunity.慢性铍病:固有免疫与获得性免疫之间的最新模型相互作用。
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Linking genetic susceptibility and T cell activation in beryllium-induced disease.将遗传易感性与铍诱导疾病中的 T 细胞激活联系起来。
Proc Am Thorac Soc. 2010 May;7(2):126-9. doi: 10.1513/pats.201002-022RM.
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4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease.4-1BB增强慢性铍病患者肺部铍特异性T细胞的增殖。
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Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells.体内暴露于无机汞会减弱金黄色葡萄球菌肠毒素B刺激的T细胞中的外源性凋亡信号传导。
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Conference summary.会议总结。
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Frequency of beryllium-specific, central memory CD4+ T cells in blood determines proliferative response.血液中铍特异性中枢记忆CD4+ T细胞的频率决定增殖反应。
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