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在存在和不存在人生长激素结合蛋白的情况下，22K或20K人生长激素对脂肪细胞中脂解作用和瘦素产生的影响。

Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein.

作者信息

Asada N, Takahashi Y, Honjo M

机构信息

Pharmaceuticals Group, Life Science Laboratory, Mitsui Chemicals, Inc., Mobara-shi, Chiba, Japan.

出版信息

Horm Res. 2000;54(4):203-7. doi: 10.1159/000053260.

DOI:10.1159/000053260
PMID:11416239
Abstract

OBJECTIVE AND METHOD

We studied the effects of human growth hormone (hGH) on leptin production and lipolysis stimulation in the presence or absence of human growth hormone binding protein (hGHBP) using 3T3- L1-hGHR adipocytes which efficiently express human growth hormone receptor.

RESULTS AND CONCLUSION

It was clarified that (1) hGH decreases leptin secretion after hGH-induced lipolysis stimulation, and (2) the reduction of leptin production and lipolysis stimulation by 22K hGH was attenuated with hGHBP, whereas that by 20K hGH, which is a naturally occurring isoform of 22K hGH, was not affected with hGHBP.

摘要

目的与方法

我们使用高效表达人生长激素受体的3T3-L1-hGHR脂肪细胞，研究了在存在或不存在人生长激素结合蛋白（hGHBP）的情况下，人生长激素（hGH）对瘦素产生和脂肪分解刺激的影响。

结果与结论

结果表明：（1）hGH在hGH诱导的脂肪分解刺激后会降低瘦素分泌；（2）22K hGH对瘦素产生和脂肪分解刺激的降低作用在hGHBP存在时减弱，而20K hGH（22K hGH的天然同工型）对瘦素产生和脂肪分解刺激的降低作用不受hGHBP影响。

相似文献

1
Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein.在存在和不存在人生长激素结合蛋白的情况下，22K或20K人生长激素对脂肪细胞中脂解作用和瘦素产生的影响。
Horm Res. 2000;54(4):203-7. doi: 10.1159/000053260.
2
GH induced lipolysis stimulation in 3T3-L1 adipocytes stably expressing hGHR: analysis on signaling pathway and activity of 20K hGH.生长激素（GH）对稳定表达人生长激素受体（hGHR）的3T3-L1脂肪细胞的脂解刺激作用：对20K hGH信号通路及活性的分析
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20 kDa human growth hormone (20K hGH) stimulates insulin-like growth factor-I (IGF-I) gene expression at lower concentrations than 22K hGH in hGH receptor-expressing Ba/F3 cells.在表达生长激素（hGH）受体的Ba/F3细胞中，20千道尔顿人生长激素（20K hGH）比22K hGH在更低浓度时就能刺激胰岛素样生长因子-I（IGF-I）基因表达。
Endocr J. 2000 Mar;47 Suppl:S37-40. doi: 10.1507/endocrj.47.supplmarch_s37.
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Analysis of binding properties between 20 kDa human growth hormone (hGH) and hGH receptor (hGHR): the binding affinity for hGHR extracellular domain and mode of receptor dimerization.20 kDa人生长激素（hGH）与人生长激素受体（hGHR）之间结合特性的分析：对hGHR细胞外结构域的结合亲和力及受体二聚化模式。
J Mol Endocrinol. 1999 Dec;23(3):347-53. doi: 10.1677/jme.0.0230347.
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The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the effect on the human prolactin receptor.20千道尔顿（kDa）的人生长激素（hGH）在对人催乳素受体的作用方面与22-kDa的hGH有所不同。
Endocrinology. 1999 Sep;140(9):3909-18. doi: 10.1210/endo.140.9.6959.
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The 20-kD human growth hormone reduces body fat by increasing lipolysis and decreasing lipoprotein lipase activity.
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The binding between the stem regions of human growth hormone (GH) receptor compensates for the weaker site 1 binding of 20-kDa human GH (hGH) than that of 22-kDa hGH.人生长激素（GH）受体茎区之间的结合弥补了20 kDa人生长激素（hGH）比22 kDa hGH在第1位点结合较弱的不足。
J Biol Chem. 2000 May 26;275(21):15652-6. doi: 10.1074/jbc.M001236200.
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Cellular activities of 20K- and 22K-hGH do not necessarily correlate with their binding affinities for rat GH receptor.20K和22K人生长激素的细胞活性与其对大鼠生长激素受体的结合亲和力不一定相关。
Horm Res. 2000;54(3):136-42. doi: 10.1159/000053247.
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Osteo-anabolic effects of human growth hormone with 22K- and 20K Daltons on human osteoblast-like cells.
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Large-scale preparation and in vitro characterization of biologically active human placental (20 and 22K) and pituitary (20K) growth hormones: placental growth hormones have no lactogenic activity in humans.生物活性人胎盘（20K和22K）及垂体（20K）生长激素的大规模制备及体外特性研究：胎盘生长激素在人体内无催乳活性。
Growth Horm IGF Res. 2006 Oct-Dec;16(5-6):297-307. doi: 10.1016/j.ghir.2006.07.002. Epub 2006 Sep 28.

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