李斯特菌中的致病岛与毒力进化
Pathogenicity islands and virulence evolution in Listeria.
作者信息
Vázquez-Boland J A, Domínguez-Bernal G, González-Zorn B, Kreft J, Goebel W
机构信息
Grupo de Patogénesis Molecular Bacteriana, Unidad de Microbiología e Inmunología, Departamento de Patología Animal I, Facultad de Veterinaria, Universidad Complutense, 28040 Madrid, Spain.
出版信息
Microbes Infect. 2001 Jun;3(7):571-84. doi: 10.1016/s1286-4579(01)01413-7.
As in other bacterial pathogens, the virulence determinants of Listeria species are clustered in genomic islands scattered along the chromosome. This review summarizes current knowledge about the structure, distribution and role in pathogenesis of Listeria virulence loci. Hypotheses about the mode of acquisition and evolution of these loci in this group of Gram-positive bacteria are presented and discussed.
与其他细菌病原体一样，李斯特菌属的毒力决定因素聚集在沿染色体散布的基因组岛中。本综述总结了关于李斯特菌毒力基因座的结构、分布及其在致病机制中作用的现有知识。本文提出并讨论了关于这些基因座在这组革兰氏阳性细菌中的获得方式和进化的假说。
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