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中国西部由[具体病菌名称缺失]引起的血流感染的临床和细菌学特征

Clinical and Bacterial Characteristics of Bloodstream Infections Caused by in Western China.

作者信息

Wang Nan, Yang Liuqing, Yuan Yu, Wu Chongyang, He Chao

机构信息

Department of Laboratory Medicine West China Hospital Sichuan University, Chengdu 610041, Sichuan, China.

出版信息

Can J Infect Dis Med Microbiol. 2024 Sep 27;2024:7785327. doi: 10.1155/2024/7785327. eCollection 2024.

DOI:10.1155/2024/7785327
PMID:39371076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11452242/
Abstract

OBJECTIVE

Bloodstream infections (BSIs) caused by are linked to high mortality of the patients. Case-specific details related to this disease and causative strains in different districts remain to be characterized.

METHODS

In this study, medical data of BSIs admitted to West China Hospital from October 2017 to March 2023 were retrieved from the hospital information system. The antimicrobial susceptibility testing and whole-genome sequencing were performed for strains isolated from blood specimens. The genetic relationship of these strains with those in public databases was also analyzed.

RESULT

The in-hospital mortality of BSIs was 25.7% (9/35). The changes in consciousness and elevated serum C-reactive protein (CRP) level were found to be the differential factors of BSIs ( < 0.05). All the 27 strains studied were susceptible to ampicillin, meropenem, and erythromycin. Only 22.2% of them were susceptible to trimethoprim-sulfamethoxazole. The pathogenicity islands 1 (LIPI-1), truncated LIPI-2, and multiple virulence-related genes outside the LIPIs were determined from these strains. Also, 12 sequence types (STs) and 12 clonal complexes (CCs) were identified and classified into clonal lineages I (9/27, 33.3%) and lineages II (18/27, 66.7%), demonstrating genetic differences with the strains in the database. ST451/CC11 (5/27, 18.5%) and ST8/CC8 (4/27, 14.8%) were the common genotypes.

CONCLUSIONS

The consciousness change and elevated serum CRP level were found to be the differential factors of BSIs. Considering the high virulence of the strains, it is needed to pay more attention to the dissemination of the predominant genotype.

摘要

目的

由[具体病原体未给出]引起的血流感染（BSIs）与患者的高死亡率相关。不同地区与该疾病及致病菌株相关的病例特定细节仍有待明确。

方法

在本研究中，从医院信息系统检索了2017年10月至2023年3月入住华西医院的BSIs患者的医学数据。对从血液标本中分离出的[具体病原体未给出]菌株进行了抗菌药物敏感性测试和全基因组测序。还分析了这些菌株与公共数据库中菌株的遗传关系。

结果

[具体病原体未给出]BSIs的院内死亡率为25.7%（9/35）。意识改变和血清C反应蛋白（CRP）水平升高被发现是[具体病原体未给出]BSIs的鉴别因素（P<0.05）。所研究的27株菌株均对氨苄西林、美罗培南和红霉素敏感。只有22.2%的菌株对复方新诺明敏感。从这些菌株中确定了致病岛1（LIPI-1）、截短的LIPI-2以及LIPIs之外的多个毒力相关基因。此外，鉴定出12种序列类型（STs）和12个克隆复合体（CCs），并分为克隆谱系I（9/27，33.3%）和谱系II（18/27,66.7%），表明与数据库中的菌株存在遗传差异。ST451/CC11（5/27，18.5%）和ST8/CC8（4/27，14.8%）是常见基因型。

结论

意识改变和血清CRP水平升高被发现是[具体病原体未给出]BSIs的鉴别因素。鉴于菌株的高毒力，需要更加关注优势基因型的传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/344260bdad29/CJIDMM2024-7785327.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/31aa57df6fad/CJIDMM2024-7785327.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/5e18209fc46f/CJIDMM2024-7785327.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/d6e195454f79/CJIDMM2024-7785327.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/4f145b28cf81/CJIDMM2024-7785327.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/344260bdad29/CJIDMM2024-7785327.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/31aa57df6fad/CJIDMM2024-7785327.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/5e18209fc46f/CJIDMM2024-7785327.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/d6e195454f79/CJIDMM2024-7785327.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/4f145b28cf81/CJIDMM2024-7785327.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9833/11452242/344260bdad29/CJIDMM2024-7785327.005.jpg

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