脑膜炎球菌病的神经发育结局：一项病例对照研究。
Neurodevelopmental outcome in meningococcal disease: a case-control study.
作者信息
Fellick J M, Sills J A, Marzouk O, Hart C A, Cooke R W, Thomson A P
机构信息
Institute of Child Health, Royal Liverpool Children's Hospital NHS Trust, Eaton Road, Liverpool L12 2AP, UK.
出版信息
Arch Dis Child. 2001 Jul;85(1):6-11. doi: 10.1136/adc.85.1.6.
AIMS
To determine long term neurodevelopmental outcome following the spectrum of meningococcal infection.
METHODS
Between 1988 and 1990, 152 cases of meningococcal disease were recruited; 139 survived. Between 1998 and 1999, 115 survivors (83%) were evaluated, together with 115 sex and age matched controls. Standard measures of neurological function, coordination, cognition, behaviour, and hearing were used to assess neurodevelopmental status.
RESULTS
One case has spastic quadriplegia. Gross neurological examination was normal in all other cases and all controls. Five cases and no controls have significant hearing loss. Cases performed at a lower level than controls on measures of coordination, cognition, and behaviour. Four cases and no controls had major impairments. The adjusted odds ratios for moderate and minor impairments were 3.6 (95% CI 1.3 to 10.3) and 1.6 (95% CI 0.8 to 3.4) respectively.
CONCLUSION
The majority of survivors from this cohort do not have gross neurological deficits. However, when objective measures of motor function, cognitive ability, and behaviour were applied significant detriments were found in meningococcal survivors.
目的
确定脑膜炎球菌感染谱后的长期神经发育结局。
方法
在1988年至1990年期间，招募了152例脑膜炎球菌病患者；139例存活。在1998年至1999年期间，对115名幸存者（83%）进行了评估，并与115名年龄和性别匹配的对照者进行了比较。采用神经功能、协调能力、认知、行为和听力的标准测量方法来评估神经发育状况。
结果
1例患有痉挛性四肢瘫痪。所有其他病例和所有对照者的大体神经检查均正常。5例患者有明显听力损失，而对照者中无此情况。在协调能力、认知和行为测量方面，患者的表现低于对照者。4例患者有严重损伤，对照者中无此情况。中度和轻度损伤的调整比值比分别为3.6（95%可信区间1.3至10.3）和1.6（95%可信区间0.8至3.4）。
结论
该队列中的大多数幸存者没有明显的神经功能缺损。然而，当应用运动功能、认知能力和行为的客观测量方法时，发现脑膜炎球菌病幸存者存在明显损害。
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