Grimwood K, Anderson P, Anderson V, Tan L, Nolan T
Department of Paediatrics, University of Melbourne, Melbourne, Australia.
Arch Dis Child. 2000 Aug;83(2):111-6. doi: 10.1136/adc.83.2.111.
To determine whether intellectual and cognitive impairments observed seven years following early childhood bacterial meningitis persist into adolescence.
Blinded neuropsychological, auditory, and behaviour assessments were conducted in 109 (69%) subjects from an original cohort of 158 children, seven and 12 years after their meningitis, and in 96 controls.
Meningitis subjects remained at greater risk than controls for any disability (odds ratio OR 4.7, confidence interval 2.2 to 9.6). Those with acute neurological complications had more sequelae than children with uncomplicated meningitis or controls (47% v 30% v 11.5% respectively; p < 0.001). Differences in intellectual, academic, and high level cognitive function between subjects and controls were maintained at the seven and 12 year assessments. In contrast, lower order skills improved, while behaviour scores deteriorated significantly (p = 0.033).
Many of the deficits identified at the seven year follow up persist 12 years after an episode of bacterial meningitis.
确定儿童早期细菌性脑膜炎7年后出现的智力和认知障碍是否会持续到青春期。
对最初158名儿童队列中的109名（69%）受试者在患脑膜炎7年和12年后进行了盲法神经心理学、听觉和行为评估，并对96名对照者进行了评估。
脑膜炎受试者出现任何残疾的风险仍高于对照组（优势比OR 4.7，置信区间2.2至9.6）。有急性神经并发症的患者比无并发症的脑膜炎患儿或对照组有更多后遗症（分别为47%对30%对11.5%；p<0.001）。在7年和12年评估时，受试者与对照组在智力、学业和高级认知功能方面的差异依然存在。相比之下，低阶技能有所改善，而行为评分显著恶化（p = 0.033）。
细菌性脑膜炎发作7年后发现的许多缺陷在12年后仍然存在。
