Department of Biology, School of Biological Sciences, College of Natural Sciences, Chungbuk National University, Cheongju 28644, Chungbuk, Korea.
Int J Mol Sci. 2020 Nov 3;21(21):8241. doi: 10.3390/ijms21218241.
Aging is the progressive decline or loss of function at the cellular, tissue, and organismal levels that ultimately leads to death. A number of external and internal factors, including diet, exercise, metabolic dysfunction, genome instability, and epigenetic imbalance, affect the lifespan of an organism. These aging factors regulate transcriptome changes related to the aging process through chromatin remodeling. Many epigenetic regulators, such as histone modification, histone variants, and ATP-dependent chromatin remodeling factors, play roles in chromatin reorganization. The key to understanding the role of gene regulatory networks in aging lies in characterizing the epigenetic regulators responsible for reorganizing and potentiating particular chromatin structures. This review covers epigenetic studies on aging, discusses the impact of epigenetic modifications on gene expression, and provides future directions in this area.
衰老是细胞、组织和机体水平上功能逐渐下降或丧失的过程，最终导致死亡。许多内外因素，包括饮食、运动、代谢功能障碍、基因组不稳定性和表观遗传失衡，影响着生物体的寿命。这些衰老因素通过染色质重塑来调节与衰老过程相关的转录组变化。许多表观遗传调节剂，如组蛋白修饰、组蛋白变体和 ATP 依赖的染色质重塑因子，在染色质重排中发挥作用。理解基因调控网络在衰老中的作用的关键在于描述负责重新组织和增强特定染色质结构的表观遗传调节剂。本综述涵盖了衰老的表观遗传学研究，讨论了表观遗传修饰对基因表达的影响，并为该领域提供了未来的研究方向。
