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我们体弱的老年患者正在服用哪些药物?他们服用或未服用的药物是否会增加药物相互作用和不适当用药的风险?

What drugs are our frail elderly patients taking? Do drugs they take or fail to take put them at increased risk of interactions and inappropriate medication use?

作者信息

Frank C, Godwin M, Verma S, Kelly A, Birenbaum A, Seguin R, Anderson J

机构信息

Department of Family Medicine, Queen's University, Kingston, Ont.

出版信息

Can Fam Physician. 2001 Jun;47:1198-204.

Abstract

OBJECTIVE

To determine whether there were discrepancies between what medications frail elderly outpatients took and what physicians thought they took and whether discrepancies put patients at risk of taking inappropriate drugs and of increasing the potential for drug interactions.

DESIGN

Case series.

SETTING

Day Hospital Program at St Mary's of the Lake Hospital in Kingston, Ont.

PARTICIPANTS

One hundred twenty community-living elderly patients attending the Day Hospital Program in 1998. Three patients and two family physicians declined to participate.

MAIN OUTCOME MEASURES

Lists of medications being taken by patients compared with lists of medications in physicians' charts. Category according to explicit criteria that each drug fell into and risk of drug interactions as determined by the Clinidata Drug Interaction Program.

RESULTS

Of the 120 patients, 115 had at least one discrepancy between their lists of medications and their physicians' lists. Of the 1390 medications on the lists, 521 (37%) were being taken by patients without their doctors' knowledge, 82 (6%) were not being taken by patients when doctors thought they were, and 133 (10%) were on both patients' and their doctors' lists but with dosages or frequency of administration that were different. More potential drug interactions were identified on patients' lists than on physicians' lists. No increase in risk of inappropriate drug use was identified.

CONCLUSION

Family physicians are often unaware of all the medications their patients are actually taking. Medications used by patients without physicians' knowledge increase the likelihood of drug interactions. Family physicians should look at and inquire about all medications, including over-the-counter drugs, their patients are actually taking.

摘要

目的

确定体弱老年门诊患者所服用的药物与医生认为他们所服用的药物之间是否存在差异,以及这些差异是否会使患者面临服用不适当药物和增加药物相互作用可能性的风险。

设计

病例系列研究。

地点

安大略省金斯顿市湖圣母医院日间医院项目。

参与者

1998年参加日间医院项目的120名社区居住老年患者。3名患者和2名家庭医生拒绝参与。

主要观察指标

将患者正在服用的药物清单与医生病历中的药物清单进行比较。根据每种药物所属的明确标准进行分类,并通过Clinidata药物相互作用程序确定药物相互作用的风险。

结果

在120名患者中,115名患者的药物清单与医生的清单之间至少存在一处差异。在清单上的1390种药物中,521种(37%)患者在医生不知情的情况下服用,82种(6%)医生认为患者服用但实际未服用,133种(10%)患者和医生的清单上都有,但剂量或给药频率不同。患者清单上发现的潜在药物相互作用比医生清单上更多。未发现不适当药物使用风险增加。

结论

家庭医生常常不知道他们的患者实际正在服用的所有药物。患者在医生不知情的情况下使用药物会增加药物相互作用的可能性。家庭医生应该查看并询问患者实际正在服用的所有药物,包括非处方药。

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