Filippi M
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
Eur J Neurol. 2001 Jul;8(4):291-7. doi: 10.1046/j.1468-1331.2001.00210.x.
In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) has markedly improved our ability to detect the macroscopic abnormalities of the brain and spinal cord. New quantitative magnetic resonance (MR) approaches with increased sensitivity to subtle normal-appearing white matter (NAWM) and grey matter changes and increased specificity to the heterogeneous pathological substrates of MS may give information complementary to conventional MRI. Magnetization transfer imaging (MTI) and diffusion-weighted imaging (DWI) have the potential to provide important information on the structural changes occurring within and outside T2-visible lesions. Magnetic resonance spectroscopy (MRS) adds information on the biochemical nature of such changes. Functional MRI might quantify the efficiency of brain plasticity in response to MS injury and improve our understanding of the link between structural damage and clinical manifestations. The present review summarizes how the application of these MR techniques to the study of MS is dramatically changing our understanding of how MS causes irreversible neurological deficits.
在多发性硬化症（MS）患者中，传统的磁共振成像（MRI）显著提高了我们检测脑和脊髓宏观异常的能力。新的定量磁共振（MR）方法对正常外观的白质（NAWM）和灰质的细微变化具有更高的敏感性，对MS异质性病理基质具有更高的特异性，可能提供与传统MRI互补的信息。磁化传递成像（MTI）和扩散加权成像（DWI）有可能提供关于T2可见病变内外发生的结构变化的重要信息。磁共振波谱（MRS）增加了有关此类变化生化性质的信息。功能MRI可能量化大脑可塑性对MS损伤的反应效率，并增进我们对结构损伤与临床表现之间联系的理解。本综述总结了这些MR技术在MS研究中的应用如何正在极大地改变我们对MS如何导致不可逆神经功能缺损的理解。
