氙气作为急性中风的神经保护剂？

Xenon as neuroprotectant in acute stroke?

作者信息

Altschuler E L

机构信息

Brain and Perception Laboratory, University of California, San Diego, 9500 Gilman Drive, 0109, La Jolla, CA 92093-0109, USA.

出版信息

Med Hypotheses. 2001 Feb;56(2):227-8. doi: 10.1054/mehy.2000.1159.

DOI:10.1054/mehy.2000.1159

PMID:11425293

Abstract

Stroke is one of the most common diseases worldwide. A current focus of research is to find neuroprotectants that can be given during acute stroke. One specific target is to find antagonists of the N-methyl-D-aspartate (NMDA) receptor in an attempt to limit glutamate associated neurotoxicity. Xenon has recently been found to be an NMDA receptor antagonist. I suggest that xenon be considered as a neuroprotectant in acute stroke, and discuss methods of testing this proposal.

摘要

中风是全球最常见的疾病之一。当前的研究重点是寻找可在急性中风期间使用的神经保护剂。一个具体目标是找到N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，以试图限制谷氨酸相关的神经毒性。最近发现氙气是一种NMDA受体拮抗剂。我建议将氙气视为急性中风中的一种神经保护剂，并讨论测试这一建议的方法。