水溶性壳聚糖衍生物的抗氧化活性。
Antioxidant activity of water-soluble chitosan derivatives.
作者信息
Xie W, Xu P, Liu Q
机构信息
Department of Chemistry, Yuquan Campus, Zhejiang University, 310027, Hangzhou, China.
出版信息
Bioorg Med Chem Lett. 2001 Jul 9;11(13):1699-701. doi: 10.1016/s0960-894x(01)00285-2.
Water-soluble chitosan derivatives were prepared by graft copolymerization of maleic acid sodium onto hydroxypropyl chitosan and carboxymethyl chitosan sodium. Their scavenging activities against hydroxyl radical *OH were investigated by chemiluminescence technique. They exhibit IC(50) values ranging from 246 to 498 microg/mL, which should be attributed to their different contents of hydroxyl and amino groups and different substituting groups.
通过马来酸钠与羟丙基壳聚糖和羧甲基壳聚糖钠的接枝共聚反应制备了水溶性壳聚糖衍生物。采用化学发光技术研究了它们对羟基自由基·OH的清除活性。它们的半数抑制浓度（IC50）值在246至498微克/毫升之间，这应归因于它们不同的羟基和氨基含量以及不同的取代基团。
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