Li Mingshan, Zhao Zhihe, Yi Jianru
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
J Funct Biomater. 2024 Aug 8;15(8):220. doi: 10.3390/jfb15080220.
Diabetes mellitus, characterized by enduring hyperglycemia, precipitates oxidative stress, engendering a spectrum of complications, notably increased bone vulnerability. The genesis of reactive oxygen species (ROS), a byproduct of oxygen metabolism, instigates oxidative detriment and impairs bone metabolism in diabetic conditions. This review delves into the mechanisms of ROS generation and its impact on bone homeostasis within the context of diabetes. Furthermore, the review summarizes the cutting-edge progress in the development of ROS-neutralizing biomaterials tailored for the amelioration of diabetic osteopathy. These biomaterials are engineered to modulate ROS dynamics, thereby mitigating inflammatory responses and facilitating bone repair. Additionally, the challenges and therapeutic prospects of ROS-targeted biomaterials in clinical application of diabetic bone disease treatment is addressed.
糖尿病以持续性高血糖为特征，会引发氧化应激，导致一系列并发症，尤其是增加骨骼的易损性。活性氧（ROS）作为氧代谢的副产物，其产生会在糖尿病状态下引发氧化损伤并损害骨代谢。本文综述深入探讨了糖尿病背景下ROS产生的机制及其对骨稳态的影响。此外，综述总结了为改善糖尿病性骨病而开发的ROS中和生物材料的前沿进展。这些生物材料经过设计可调节ROS动态，从而减轻炎症反应并促进骨修复。此外，还讨论了ROS靶向生物材料在糖尿病骨病治疗临床应用中的挑战和治疗前景。
