β-淀粉样蛋白肽及其在阿尔茨海默病中的作用。
The amyloid-beta peptide and its role in Alzheimer's disease.
作者信息
Clippingdale A B, Wade J D, Barrow C J
机构信息
School of Chemistry, The University of Melbourne, Victoria, Australia.
出版信息
J Pept Sci. 2001 May;7(5):227-49. doi: 10.1002/psc.324.
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of A beta synthesis, purification and structural analysis. Also discussed are proposed mechanisms for A beta-induced neurotoxicity and some recent advances in the development of A beta-related therapeutic strategies.
淀粉样蛋白的形成在阿尔茨海默病的病因和进展中起着核心作用。这种淀粉样蛋白的主要成分是β淀粉样蛋白（Aβ）肽，它目前是深入研究的对象。这篇综述讨论了在Aβ合成、纯化和结构分析领域的一些最新研究。还讨论了Aβ诱导神经毒性的机制以及Aβ相关治疗策略开发方面的一些最新进展。
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