Matsuda T, Nomi M, Ikeya M, Kani S, Oishi I, Terashima T, Takada S, Minami Y
Department of Biomedical Regulation, Kobe University, School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan.
Mech Dev. 2001 Jul;105(1-2):153-6. doi: 10.1016/s0925-4773(01)00383-5.
In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror1 and Ror2 during early embryogenesis were examined and compared. Interestingly, at early stages, Ror1 and Ror2 exhibit similar expression patterns in the developing face, including the frontonasal process and pharyngeal arches, which are derived from cephalic neural crest cells. On the other hand, they exhibit different expression patterns in the developing limbs and brain, where the expression of Ror2 was detected broadly compared with that of Ror1. At a later stage, both genes are expressed in a similar fashion in the developing heart and lung, yet in a distinct manner in the brain and eye.
在哺乳动物中，Ror家族受体酪氨酸激酶由两种结构相关的蛋白质Ror1和Ror2组成，其特征是具有细胞外类卷曲蛋白富含半胱氨酸结构域和膜近端kringle结构域。为了深入了解它们在小鼠发育中的作用，研究并比较了Ror1和Ror2在早期胚胎发生过程中的表达模式。有趣的是，在早期阶段，Ror1和Ror2在发育中的面部表现出相似的表达模式，包括额鼻突和咽弓，它们源自头部神经嵴细胞。另一方面，它们在发育中的四肢和大脑中表现出不同的表达模式，与Ror1相比，Ror2的表达在这些部位广泛检测到。在后期阶段，这两个基因在发育中的心脏和肺中以相似的方式表达，但在大脑和眼睛中则以不同的方式表达。
