Katritzky A R, Mehta S, He H Y
Center for Heterocyclic Chemistry, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA.
J Org Chem. 2001 Jan 12;66(1):148-52. doi: 10.1021/jo001273f.
1,5,6,10b-Tetrahydropyrrolo[2,1-alpha]isoquinolin-3(2H)-ones 17a,b, 17d,e, and 5,12b-dihydroisoindolo[1,2-alpha]isoquinolin-8(6H)-ones 22a-e were prepared by intramolecular cyclizations of 1-(2-arylethyl)-5-benzotriazolyl-pyrrolidin-2-ones 15a,b, 15d,e, and 3-benzotriazolyl-2-(2-arylethyl)-1-isoindolinones 20a-e, respectively, in the presence of titanium chloride. Products from chiral amines were obtained with stereoselectivities of > or = 94%.
通过分别在氯化钛存在下，使1-(2-芳基乙基)-5-苯并三唑基吡咯烷-2-酮15a、b、15d、e和3-苯并三唑基-2-(2-芳基乙基)-1-异吲哚啉酮20a、e进行分子内环化反应，制备了1,5,6,10b-四氢吡咯并[2,1-α]异喹啉-3(2H)-酮17a、b、17d、e和5,12b-二氢异吲哚并[1,2-α]异喹啉-8(6H)-酮22a - e。从手性胺得到的产物的立体选择性≥94%。
