Robertson I
Med J Aust. 1975 May 3;1(18):571-3. doi: 10.5694/j.1326-5377.1975.tb111590.x.
Hypermobility of the joints is a frequent finding in patients who have keratoconus. Twenty-two of 44 patients (50%) presenting in 1973 were found to have hypermobility of joints (mainly Ehlers-Danlos syndrome II or mitis type). The significance of this finding is discussed in relation to biochemical defects recently found in corneas with keratoconus. The hypothesis is presented that keratoconus is often a part of a generalized heritable disorder of connective tissue due to a biochemical defect causing a weakness in its structure.
关节活动过度在圆锥角膜患者中是常见表现。1973年就诊的44例患者中有22例（50%）被发现存在关节活动过度（主要为埃勒斯-当洛综合征II型或轻型）。结合近期在圆锥角膜患者角膜中发现的生化缺陷，对这一发现的意义进行了讨论。本文提出一种假说，即圆锥角膜通常是由于生化缺陷导致结缔组织结构薄弱而引起的一种全身性遗传性疾病的一部分。
