圆锥角膜的全身及眼部关联
Systemic and Ocular Associations of Keratoconus.
作者信息
Hefley Brenna S, Ali Arsalan A, Bhattacharya Pradipta, Hjortdal Jesper, Walker Maria K, Karamichos Dimitrios
机构信息
North Texas EAye Research Institute, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Department of Pharmaceutical Sciences, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
出版信息
Expert Rev Ophthalmol. 2024;19(5):379-391. doi: 10.1080/17469899.2024.2368801. Epub 2024 Jul 3.
INTRODUCTION
Keratoconus (KC) is the most prevalent corneal ectasia in the world and its pathogenesis is influenced by both ocular and systemic factors. This review explores the multifaceted associations between keratoconus and systemic health conditions, ocular characteristics, and various other environmental/exogenous factors, aiming to illuminate how these relationships influence the pathophysiology of the disease.
AREAS COVERED
This review will summarize the fundamental attributes of KC, review and discuss the systemic and ocular association of KC including molecular biomarkers, and provide an organized overview of the parallel alterations occurring within various biological pathways in KC.
EXPERT OPINION
Despite the substantial volume of research on keratoconus, the precise etiology of the disease remains elusive. Further studies are necessary to deepen our understanding of this intricate disorder and improve its management.
引言
圆锥角膜（KC）是全球最常见的角膜扩张性疾病，其发病机制受眼部和全身因素的影响。本综述探讨了圆锥角膜与全身健康状况、眼部特征以及各种其他环境/外源性因素之间的多方面关联，旨在阐明这些关系如何影响该疾病的病理生理学。
涵盖领域
本综述将总结圆锥角膜的基本特征，回顾并讨论圆锥角膜的全身和眼部关联，包括分子生物标志物，并对圆锥角膜各种生物学途径中发生的平行改变进行有条理的概述。
专家观点
尽管对圆锥角膜已有大量研究，但该疾病的确切病因仍不清楚。有必要进行进一步研究，以加深我们对这种复杂疾病的理解并改善其治疗。
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