Kleiter M, Hirt R, Kirtz G, Day M J
I. Medical Clinic for Small Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Aust Vet J. 2001 May;79(5):335-8. doi: 10.1111/j.1751-0813.2001.tb12007.x.
A 7-year-old male Giant Schnauzer was referred with a history of severe vomiting, lethargy, weight loss, polydipsia and polyuria. Detailed investigations revealed leucocytosis with a marked lymphocytosis, mild non-regenerative anaemia, thrombocytopenia, hypercalcaemia and azotaemia. Circulating lymphocytes were small and well-differentiated, and the same lymphoid population was present in bone marrow. Chronic lymphocyctic leukaemia with associated paraneoplastic hypercalcaemia was diagnosed. Immunohistochemical staining of a bone marrow biopsy revealed a neoplastic B-cell line expressing CD79. The dog responded to therapy with prednisolone and chlorambucil for a period of 8 months.
一只7岁雄性巨型雪纳瑞犬因严重呕吐、嗜睡、体重减轻、多饮多尿病史前来就诊。详细检查发现白细胞增多伴显著淋巴细胞增多、轻度非再生性贫血、血小板减少、高钙血症和氮质血症。循环淋巴细胞小且分化良好，骨髓中也存在相同的淋巴细胞群。诊断为慢性淋巴细胞白血病伴副肿瘤性高钙血症。骨髓活检的免疫组织化学染色显示肿瘤性B细胞系表达CD79。这只狗接受泼尼松龙和苯丁酸氮芥治疗8个月后有反应。
