Schiavo G, van der Goot F G
Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Nat Rev Mol Cell Biol. 2001 Jul;2(7):530-7. doi: 10.1038/35080089.
Pathogenic bacteria and higher eukaryotes have spent a long time together, leading to a precise understanding of one another's way of functioning. Through rapid evolution, bacteria have engineered increasingly sophisticated weapons to hit exactly where it hurts, interfering with fundamental host functions. However, toxins are not only useful to the bacteria - they have also become an essential asset for life scientists, who can now use them as toolkits to explore cellular processes.
致病细菌与高等真核生物长期共存,从而对彼此的运作方式有了精准的了解。通过快速进化,细菌制造出了越来越复杂的武器,精准地攻击宿主的要害部位,干扰宿主的基本功能。然而,毒素不仅对细菌有用——它们也已成为生命科学家的重要资产,科学家现在可以将它们用作探索细胞过程的工具包。