离体大鼠神经垂体中血管加压素释放缺乏毒蕈碱调节。

Isolated rat neurohypophyses were incubated in Locke solution at 37 degress C and the vasopressin output into the medium determined by bioassay. 2. Potassium chloride 60 mM caused a 9-fold increase in the rate of vasopressin release that was abolished when calcium chloride was omitted from the Locke solution. 3. Acetylcholine 5.5x10-4M neither alone nor in the presence of atropine 2.9x10-6M changed the "resting" release of vasopressin. 4. Neither acetylcholine 5.5x10-4M oxotremorine 10-4 and k3x10-4M altered the vasopressin release evoked by potassium chloride 60 mM. 5. In contrast to the peripheral adrenergic nerve fibres, the secretory terminal fibres of the neurohypophysis do not appear to contain muscarinic inhibitory or nicotinic excitatory receptors.

将分离的大鼠神经垂体在37摄氏度的洛克溶液中孵育，通过生物测定法测定释放到培养基中的抗利尿激素量。2. 60毫摩尔的氯化钾使抗利尿激素释放速率增加了9倍，当洛克溶液中省略氯化钙时，这种增加被消除。3. 5.5×10⁻⁴摩尔的乙酰胆碱单独使用或在2.9×10⁻⁶摩尔阿托品存在的情况下，都不会改变抗利尿激素的“基础”释放。4. 5.5×10⁻⁴摩尔的乙酰胆碱、10⁻⁴摩尔的氧化震颤素和3×10⁻⁴摩尔的K都不会改变60毫摩尔氯化钾引起的抗利尿激素释放。5. 与外周肾上腺素能神经纤维不同，神经垂体的分泌终末纤维似乎不含有毒蕈碱抑制性或烟碱兴奋性受体。

Absence of muscarinic modulation of vasopressin release from the isolated rat neurophypophysis.