抑制钠泵可增强大鼠离体神经垂体中钙依赖的血管加压素释放。

Inhibition of Na pumps enhances Ca-dependent release of vasopressin from the isolated neurohypophysis of the rat.

作者信息

Sorimachi M

出版信息

Jpn J Physiol. 1983;33(6):1061-6. doi: 10.2170/jjphysiol.33.1061.

DOI:10.2170/jjphysiol.33.1061

Abstract

The isolated neurohypophysis of the rat was incubated with a medium lacking Ca and vasopressin release was induced by reintroduction of Ca (2 mM). The response to Ca was greatly enhanced after treatment with a medium containing ouabain or lacking K. The enhanced release of vasopressin by ouabain was dependent on the concentration of external Na. The results suggest that inhibition of Na pumps leads to a rise in internal Na, thereby activating Na-dependent Ca influx mechanism associated with vasopressin release.

摘要

将大鼠分离出的神经垂体与不含钙的培养基一起孵育，然后重新加入钙（2 mM）诱导血管加压素释放。用含有哇巴因的培养基处理或不含钾的培养基处理后，对钙的反应大大增强。哇巴因增强血管加压素释放取决于细胞外钠的浓度。结果表明，钠泵的抑制导致细胞内钠升高，从而激活与血管加压素释放相关的钠依赖性钙内流机制。