Segasothy M, Phillips P A
Department of Medicine, Northern Territory Clinical School of Medicine of Flinders University, Alice Springs, Australia.
Lupus. 2001;10(6):439-44. doi: 10.1191/096120301678646191.
The objective of this study was to determine whether there are differences in the prevalence, clinical and laboratory manifestations, and morbidity and mortality of systemic lupus erythematosus (SLE) between Aborigines and Caucasians in Central Australia. The medical records of all patients diagnosed with SLE upto December 1999 were reviewed retrospectively. Prevalence of SLE was 1:1360 for Aborigines and 1:5170 for Caucasians. The prevalences of malar rash, discoid rash, photosensitivity, oral ulcers, pleuritis, anticardiolipin antibodies and lupus anticoagulant were higher in Caucasians than in Aborigines. The prevalences of anti-Sm antibody and anti-RNP antibody were higher in Aborigines than in Caucasians. These differences did not attain statistical significance. There was a low prevalence of renal disease in Aborigines and Caucasians. Mortality was low in Aborigines and nil in Caucasians. Although there is a high prevalence of SLE in Aborigines in Central Australia, renal involvement and mortality are low.
本研究的目的是确定澳大利亚中部原住民和白种人在系统性红斑狼疮（SLE）的患病率、临床及实验室表现以及发病率和死亡率方面是否存在差异。对截至1999年12月所有诊断为SLE的患者的病历进行了回顾性分析。原住民SLE患病率为1:1360，白种人为1:5170。白种人颊部红斑、盘状红斑、光过敏、口腔溃疡、胸膜炎、抗心磷脂抗体和狼疮抗凝物的患病率高于原住民。原住民抗Sm抗体和抗RNP抗体的患病率高于白种人。这些差异无统计学意义。原住民和白种人肾病患病率均较低。原住民死亡率较低，白种人无死亡病例。尽管澳大利亚中部原住民SLE患病率较高，但肾脏受累及死亡率较低。
