Chang C C, Shih T Y, Chu S J, Kuo S Y, Chen C M, Hsu C M, Chang M L, Chang D M
Department of Internal Medicine, Taipei Municipal Jen-Ai Hospital, Taiwan, R.O.C.
Zhonghua Yi Xue Za Zhi (Taipei). 1995 Feb;55(2):143-50.
Systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, and is uncommon in men. In recent years, several large clinical series of male lupus patients have been reported. As no known data are available for lupus in males from Taiwan, a retrospective analysis of data from male lupus patients was done to determine whether these patients differed from other series of male or female SLE patients in the literature.
Sixty-one male lupus patients, diagnosed and followed in Tri-Service General Hospital, between 1983 and 1993, were studied and their data analyzed, retrospectively.
The mean age of diagnosis was 30 +/- 17 (mean +/- SD, range: 13-81) years. The peak age of diagnosis was between 13 and 40 years. The mean duration of follow-up was 36 +/- 36 (range: 2-256) months. The 1-, 5- and 10-year survival rates were 84%, 76% and 75%, respectively. The frequency of clinical manifestations were renal disease, 75%; malar rash, 70%; arthritis, 60%; fever, 56%; photosensitivity, 48%; pleuritis, 39%; pericarditis, 31%; alopecia, 31%; mucosal ulcers, 29%; neuropsychiatric disease, 26%; discoid lupus, 21%; vasculitis, 15%; Raynaud's phenomenon, 10%; and lymphadenopathy, 2%. The frequency of abnormal laboratory findings were antinuclear antibodies (ANA), 95%; hypocomplementemia, 77%; antibodies to double-stranded DNA (anti-dsDNA), 57%; leukopenia, 44%; lupus erythematosus (LE) cells, 39%; anti-Ro, 39%; anti-Smith antibodies (anti-Sm), 19%; thrombocytopenia, 18%; rheumatoid factor, 17%; anti-ribonucleoprotein antibody (anti-RNP), 14%; autoimmune hemolytic anemia, 8%; false-positive venereal disease research laboratory test (VDRL), 6% and anti-La, 4%.
In a review of the 61 ethnic Chinese male lupus patients, a higher frequency of renal disease, malar rash and photosensitivity, but a lower frequency of arthritis and lymphadenopathy, compared to previous reports of Caucasians. There were no significant immunological differences from other series of male lupus, except a lower frequency of anti-dsDNA. In general, poor prognosis was noted for male lupus patients here.
系统性红斑狼疮（SLE）传统上被认为是一种女性疾病，在男性中并不常见。近年来，已有数篇关于男性狼疮患者的大型临床系列报道。由于台湾地区尚无关于男性狼疮的已知数据，因此对男性狼疮患者的数据进行了回顾性分析，以确定这些患者与文献中其他系列的男性或女性SLE患者是否存在差异。
对1983年至1993年间在三军总医院诊断并随访的61例男性狼疮患者进行研究，并对其数据进行回顾性分析。
诊断时的平均年龄为30±17（平均±标准差，范围：13 - 81）岁。诊断的高峰年龄在13至40岁之间。平均随访时间为36±36（范围：2 - 256）个月。1年、5年和10年生存率分别为84%、76%和75%。临床表现的发生率为：肾脏疾病75%；颊部皮疹70%；关节炎60%；发热56%；光敏性48%；胸膜炎39%；心包炎31%；脱发31%；黏膜溃疡29%；神经精神疾病26%；盘状狼疮21%；血管炎15%；雷诺现象10%；淋巴结病2%。实验室检查异常的发生率为：抗核抗体（ANA）95%；低补体血症77%；双链DNA抗体（抗dsDNA）5
