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[镇痛剂诱发的慢性头痛]

[Analgesic-induced chronic headache].

作者信息

Le Jeunne C

机构信息

Service de Médecine Interne et de Thérapeutique, Hôpital Européen Georges-Pompidou, 20, rue Leblanc, 75015 Paris.

出版信息

Ann Med Interne (Paris). 2001 Apr;152 Suppl 3:IS50-3.

Abstract

Analgesic-induced chronic headaches are the outcome of an overtreatment of migraine or tension type headaches. Progressively, the usual headache changes and becomes a chronic daily headache occurring in the morning when waking up, relieved 1 hour after intake of the concerned analgesic. If drug intake is delayed, the daily headache disappears after 4 weeks following a period of worsening. This withdrawal therapy is often conducted during a 2-week hospitalization. Drugs mainly implicated in this type of dependence are: caffeine, ergotamine, simple analgesics, and triptans which are becoming more and more involved. The best treatment is prevention. When first seen, patients must be warned of the risk of chronic use of analgesics.

摘要

镇痛药诱发的慢性头痛是偏头痛或紧张型头痛过度治疗的结果。逐渐地,通常的头痛会发生变化,变成晨起时出现的慢性每日头痛,服用相关镇痛药1小时后缓解。如果延迟服药,经过一段时间的恶化后,每日头痛会在4周后消失。这种撤药疗法通常在为期2周的住院期间进行。主要涉及此类依赖性的药物有:咖啡因、麦角胺、单纯镇痛药以及越来越多涉及其中的曲坦类药物。最佳治疗方法是预防。初次就诊时,必须告诫患者长期使用镇痛药的风险。

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