Ferretti P G, Marchini L, Africa A, Passeri M
Minerva Med. 1975 Apr 28;66(32):1509-18.
The importance of loading tests, particularly venous loading with fructose, in the determination of changes in purine metabolism is stressed. Such changes may well be present even if basic uricaemia is within the limits of normal. Fructose loading was used to determine the hypouricaemising and uricosuric effects of a mediomineral water in aged subjects following daily administration. A hypouricaemising effect was noted and there was an improvement in loading curve patterns. This effect is considered to be primarily due to the uricosuric activity of the water itself. Sugar tolerance and the insulin response to loading, on the other hand, were not altered by the treatment.
强调了负荷试验，尤其是果糖静脉负荷试验在确定嘌呤代谢变化中的重要性。即使基础血尿酸水平在正常范围内，也很可能存在此类变化。果糖负荷试验用于确定一种中矿质水在老年受试者每日服用后降低血尿酸和促尿酸尿的作用。观察到有降低血尿酸的作用，并且负荷曲线模式有所改善。这种作用被认为主要归因于水本身的促尿酸尿活性。另一方面，治疗并未改变糖耐量和负荷后的胰岛素反应。
