Tarello W
Comp Immunol Microbiol Infect Dis. 2001 Jul;24(3):165-85. doi: 10.1016/s0147-9571(00)00025-4.
A great deal of controversy and speculation surrounds the etiology of Chronic Fatigue Syndrome (CFS) in human patients and the existence of a similar illness in animals. To evaluate the association with a presumptive staphylococcal infection and bacteremia, seven dogs and eight cats diagnosed with CFS (two meeting the CDC working case definition) were submitted to rapid blood cultures and fresh blood smears investigations. Nine out of 15 blood cultures proved Staph-positive and four isolates were specified as S. xilosus (3) and S. intermedius (1). The presence of micrococci-like organisms in the blood was of common observation among these subjects, in association with fatigue/pain-related symptoms and biochemical abnormalities suggestive of a myopathy. Following treatment with a low dosage arsenical drug (thiacetarsamide sodium, Caparsolate, i.v., 0.1 ml/kg/day) all patients experienced complete remission. Micrococci disappeared from the blood at post-treatment controls made 10-30 days later. The outcomes were compared with those of five healthy controls and five 'sick with other illness' patients showing significant difference.
围绕人类慢性疲劳综合征（CFS）的病因以及动物中类似疾病的存在，存在大量争议和猜测。为了评估与假定的葡萄球菌感染和菌血症的关联，对7只狗和8只被诊断为CFS的猫（其中两只符合美国疾病控制与预防中心的工作病例定义）进行了快速血培养和新鲜血液涂片检查。15份血培养中有9份被证明为葡萄球菌阳性，4株分离菌被鉴定为木糖葡萄球菌（3株）和中间葡萄球菌（1株）。在这些受试动物中，血液中存在微球菌样生物体是常见现象，同时伴有与疲劳/疼痛相关的症状以及提示肌病的生化异常。在用低剂量砷剂药物（硫代乙酰胂酸钠，卡巴胂，静脉注射，0.1毫升/千克/天）治疗后，所有受试动物均完全缓解。在治疗后10 - 30天进行的对照检查中，微球菌从血液中消失。将结果与5只健康对照动物和5只“患有其他疾病”的动物进行比较，显示出显著差异。
